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The
Rumbaugh-Goodwin Institute for Cancer Research, Inc.
at Nova Southeast University (RGI) www.rgicr.org ,
a non-profit 501(c)(3) organization, was established
in 1959 and is located in Plantation, FL, just outside
of Fort Lauderdale. RGI is committed to rapidly developing
anti-cancer therapies, in conjunction with industrial
and academic partners, using efficient models of cancer
growth and metastasis with the aim of moving novel
compounds to market in the shortest time possible. Additionally,
RGI is investigating 1) why cancer becomes resistant
to chemotherapy over time, 2) how this resistance can
be overcome, 3) which chemotherapeutic agents are most
likely to work in a particular individual and 4) what
causes cancer
to spread. The Institute’s main goal is to develop
cancer therapies targeting tumors,
with minimal cellular damage
and toxicity to the patient. Its long- |
| standing relationship
with the National Cancer Institute (NCI) and The National
Institute of Health (NIH) provides support for the
advancement and development of these kinds of promising
new investigational therapies.
RGI has excellent laboratory facilities, a dedicated research staff and a passion
for getting new treatments to patients quickly. Their ability to move
towards our research goals is facilitated by numerous generous donations, government
grants and collaborations with academic and industrial partners. They are very
proud to be supported by the Royal Dames of Cancer Research.
RGI plans to continue its ongoing basic research as well as anti-cancer drug
screening. Particular emphasis will be placed on research conducted with its
unique human xenograft model and cell line derivative that won RGI recognition
from the NCI and various academic institutions. The aims of the major research
programs are to:
- Study mechanisms of metastasis and
tumor growth
- Discover new anti-metastatic therapies
- Identify critical growth factors/receptors
for breast tumor development
- Demonstrate anti-metastasis suppressor
genes and enhanced expression of several metastasis
associated proteins in breast tumor xenograft and
cell lines
- Evaluate chemotherapeutic/biotherapeutic
agents effective against breast cancer
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